MARKS &Spencer is to close its Simply Food store in Ruislip High Street.
The lease is not being renewed and the store will close over the summer.
A spokesman said there were several stores nearby and the 25 staff would be redeployed.
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Ryan Kerr, Head of Region for North London, said: “The decision was a difficult one to make. Our 35 colleagues will all move to nearby stores including Pinner and Uxbridge.”
The announcement comes after M&S reported a 61.1% fall in pre-tax profit to £66.8m in the year to March 31.
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